子宫内膜异位症患者检测腹腔液及血清IL-4、IL-8价值分析

Value of Detecting Serum and Peritoneal Fluid Levels of IL-4 and IL-8 in Patients with Endometriosis

目的探讨子宫内膜异位症(endometriosis,EMS)患者腹腔液及血清中IL-4、IL-8的变化及意义.方法采用酶联免疫吸附双抗体夹心法(ELISA)检测48例内异症患者(Ⅰ～Ⅱ期21例,Ⅲ～Ⅳ期27例)及18例对照组(其他妇科手术,术中可见腹腔积液者)腹腔液及血清中IL-4、IL-8含量.结果子宫膜异位症组的腹腔液及血清IL-4、IL-8含量均高于对照组,差异有统计学意义(P<0.05);EMS组Ⅲ～Ⅳ期腹腔液IL-4、IL-8和血清均高于Ⅰ、Ⅱ期腹腔液和血清含量,差异均有统计学意义(P<0.05);EMS组术前后血清中IL-4、IL-8含量比较,差异有统计学意义(P<0.05).结论 IL-4、IL-8在EMS发病中起重要作用,检测其含量变化有助于该病的诊断和治疗.

Objective To explore the changes and and ]L-8 in patients with endometriosis. Method significance of serum and peritoneal fluid levels of IL-4 By using double antibody sandwich enzyme-linked immunosorbent assay （ELISA） , we detected the 48 patients with endometriosis （21 patients in I - II and 27 patients in III- IV） and 18 patients in the control group （who received other gynecological surgery with intraoperative intraperitoneal effusion）. Results The peritoneal fluid and serum levels of IL-4 and [L-8 in patients with endometriosis were higher than those in patients without endometriosis in control group （P 〈 0.05 ）. In EMs group, the peritoneal fluid and serum levels of IL-4 and IL-8 in patients in m ~ 1V stage were higher than those in patients in I ~ II stage （P 〈 0.05 ）. Conclusion IL-4 and IL-8 play an important role in the pathogenesis of endometriosis, detecting the changes of lL-4 and IL-8 levels in serum and peritoneal fluid may benefits the diagnosis and treatment of endometriosis. ,.