发展性阅读障碍的遗传关联分析

The Genetic Association Analysis on Developmental Dyslexia

发展性阅读障碍是一种遗传性很高的认知功能缺陷,运用关联分析对其遗传机制进行研究是近年来的新趋势。从研究方法的视角可以将现有的关联分析研究归为以下三类:家系法研究、病例-控制法研究和数量性状关联分析研究。阅读障碍关联分析研究的新趋势主要体现在与全基因组扫描技术、神经成像技术以及基因功能研究的结合上,促进了从"基因-大脑-行为"层面对发展性阅读障碍的遗传机制进行理解。

Developmental dyslexia is a highly heritable mental disorder. In the last decade, utilizing association analysis to uncover genetic mechanisms of dyslexia has become a new trend. In terms of methodology, research in association analysis can be divided into three approaches： family based studies, case-control studies and quantitative trait association studies. Combined with other techniques, such as genome-wide scan, neuroimaging and gene function, this new trend enables researchers better examine genetic mechanisms of developmental dyslexia from multiple perspectives across gene, brain, and behavior.