先天性睑裂狭小基因FOXL2与卵巢早衰相关性的研究进展

Research progress of relationship between congenital blepharophimosis gene FOXL2 and premature ovarian failure

据流行病学调查统计,卵巢早衰(POF)发病率呈上升趋势,在女性中发病率约1%。资料显示POF与遗传因素有关,可能是一种潜在的多基因遗传病,且极具遗传特质。先天性睑裂狭小基因(winged helix/forkhead transcription factorgene2,FOXL2)是第一个被认为在维持卵巢功能方面发挥重要作用的人类常染色体基因。近来,FOXL2与POF的关系备受关注,本文就最新进展作一综述。

According to the epidemiological survey, the incidence of premature ovarian failure （POF） is rising, which is about 1% in women. POF is associated with genetic factors and possesses great genetic characteristics. POF may be potential genetic diseases involved multiple gene. Congenital blepharophimosis gene （winged helix/forkhead transcription factor gene2, FOXL2） was the first human autosomal gene which was considered to play an important role in the maintenance of ovarian function. Recently, the relationship between FOXL2 and premature ovarian failure attracts much attention. This article reviewed the latest advances.