青蒿水提液对家兔心血管和呼吸功能的影响

Effects of Artemisinin extract on the cardiovascular and respiratory function in rabbits

目的:观察青蒿水提液对正常家兔心血管和呼吸功能的影响。方法:32只健康新西兰大白兔随机分为4组,分别对其静脉注射10 ml/kg的生理盐水,10、100 mg/kg和500 mg/kg的青蒿水提液,连续用药第12天时,记录各实验兔的动脉血压、心电图与呼吸运动;动脉血气分析和肺组织学观察。结果:与对照组比较:(1)各实验组对家兔动脉血压、心率、心电图与呼吸运动均未见明显改变(P>0.05)。(2)高剂量组PaO2下降,P<0.05,其余组pH值、PaCO2、PaO2、HCO3-、BE和SaO2未见明显改变,P>0.05。结论:青蒿水提液对家兔的心血管系统功能未产生明显毒副作用,但在较高剂量时会造成家兔肺组织炎症反应。

Objective：To observe the effects of Artemisinin extract on the cardiovascular and respiratory function in rabbits.Methods：Thirty-two healthy New Zealand white rabbits were randomly assigned to four groups.10 ml/kg normal saline,10,100 mg/kg and 500 mg/kg Artemisinin extract were injected respectively into the rats in the four groups.Arterial blood pressure,respiratory movement,electrocardiogram,blood gas analysis and histological examination of the lungs in the experimental rabbits were measured on 12th d after the intravenous injection.Results：Compared with those in the control group,（1）there was no difference in blood pressure,respiratory movement,heart rate and electrocardiogram among each experimental group（P 〉0.05）;（2）the values of pH,PaCO2,PaO2,HCO3ˉ,BE and SaO2 were not statistically changed in low and middle dosage groups（P 〉0.05）,but the PaO2 value was decreased significantly in high dosage group（P〈0.05）.Conclusions：Artemisinin extract will not exert obvious adverse effect on the cardiovascular system in rabbits,but the pulmonary inflammatory response can be induced by high-dose Artemisinin extract in experimental rabbits.