子宫内膜异位症患者血清骨桥蛋白抗体及转铁蛋白抗体水平分析

Levels of anti-osteopontin and anti-transferrin antibodies in sera of patients with endometriosis

目的:探讨血清中骨桥蛋白抗体和转铁蛋白抗体与子宫内膜异位症的关系。方法:用酶联免疫吸附试验方法检测108例子宫内膜异位症患者及88例健康妇女血清中骨桥蛋白抗体及转铁蛋白抗体水平。结果:子宫内膜异位症患者血清中骨桥蛋白抗体OD值为0.84±0.25,对照组为0.63±0.20;转铁蛋白抗体OD值为1.06±0.31,对照组为0.75±0.27,子宫内膜异位症组均明显高于对照组(均P<0.05)。子宫内膜异位症Ⅰ、Ⅱ期患者血清骨桥蛋白抗体OD值(1.04±0.30)明显高于Ⅲ、Ⅳ期患者(0.68±0.20)及对照组妇女(0.63±0.20)(均P<0.05)。子宫内膜异位症组转铁蛋白抗体阳性率为25.0%(27/108),骨桥蛋白抗体阳性率为20.3%(22/108),两者均阳性占13.9%(15/108),与对照组相比差异有统计学意义(P<0.05)。相关分析发现子宫内膜异位症患者血清中转铁蛋白抗体水平与骨桥蛋白抗体水平呈正相关(r=0.875,P<0.05)。结论:抗骨桥蛋白抗体可能与子宫内膜异位症的发展有关。

Objective ： To explore the pathogenesis of endometriosis by evaluating levels of anti - osteopontin and anti - transferrin antibodies in sera. Methods ： The enzyme - linked immunosorbent assay was used to detect levels of anti - osteopontin and anti -transferrin antibodies in sera of 108 women with endometriosis and 88 healthy women （the control）. Results： The average OD values of anti - osteopontin antibody in sera of women with endometriosis and the control were 0.84 ±0.25 and 0. 63± 0.20, respectively. The average OD values of anti - transferrin antibody in sera of women with endometriosis and the control were 1.06 ± 0.31 and 0.75 ± 0.27, respectively. The level of anti - osteopontin antibody in sera of women with stage I and stage II endometriosis （ 1.04± 0.30） was significantly higher than those of women with stage III and stage IV endometriosis （0.68 ± 0.20） and the control （0.63 ＋ 0.20, P all 〈 0.05 ）. The positive rates of anti - osteopontin, anti - transferrin antibodies and both were 25.0% （27/108）, 20.3% （22/108） and 13.9% （15/108）, significantly higher than that of the control （ P all 〈 0.05 ）. The positive correlation between anti - osteopontin antibody level and anti - transferrin antibody level was found. Conclusion ： Anti - osteopontin antibody may be involved in the development of endometriosis.