狼疮性脂膜炎8例临床分析

Lupus Erythematosus Panniculitis:Clinical Analysis of 8 Cases

目的:了解狼疮性脂膜炎的临床特征,提高对本病的认识。方法:回顾性分析在我中心皮肤科门诊收治的8例确诊为狼疮性脂膜炎的患者的临床、组织病理特点及治疗预后情况。结果:皮损好发于头面部、上肢及臀部,临床表现为皮肤萎缩、红斑、皮下结节、浸润性红斑及皮肤破溃。病理的典型改变为皮下脂肪层出现淋巴细胞浸润为主的小叶性脂膜炎。治疗以硫酸羟氯喹单用或合用激素为主,大多数患者对治疗反应较好。结论:狼疮性脂膜炎较少见,其典型的临床和病理特征是诊断的要点,硫酸羟氯喹及中小剂量糖皮质激素治疗有效。

Objective：To investigate the clinical features of lupus erythematosus panniculitis （ LEP）, and to enhance awareness of the disease and the retrospective a- nalysis of the clinical data from 8 patients with lupus panniculitis from outpatient department of dermatology in our center＇was conducted including clinical, pathological features, treatment mo- dality and prognosis. Results：Skin lesions of LEP presented as atrophy, erythema, subcutaneous nodules, infiltrated erythema and ulceration over the scalp, face, upper limbs and buttock. His- topathological features showed lobular panniculitis in the subcutaneous fatty tissue. Hydroxychloro- quine sulfate alone or combined with corticosteroid were p/＇escr/bed and most of the patients re- sponded well to the treatment. Conclusion：LEP is a rare cutaneous variant of lupus erythemato- sus. The diagnosis of LEP is mainly based on clinical findings and pathological features. Hydroxy- chloroquine sulfate and low-and middle-dose corticosteroid are effective in the treatment of LEP.