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Th22细胞及其细胞因子在银屑病发病机制中的作用 被引量：7

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摘要 银屑病是一种由T细胞介导的疾病,以表皮过度增殖、角质形成细胞异常分化伴血管增生及皮损处免疫细胞浸润为特征。近来发现了一群独立于Th1、Th2及Th17细胞的新型CD4+记忆性T细胞——Th22细胞,其在银屑病等一些炎症性皮肤病中不同程度升高,使免疫调节机制进一步完善,通过了解其作用机理或许可开展将其作为一个治疗银屑病的新型靶点的研究。本文就Th22细胞及其细胞因子在银屑病中的作用机制进行综述。
作者 辛甜甜 王晓华 陈永锋
机构地区 广东省皮肤性病防治中心 广东医学院
出处 《皮肤性病诊疗学杂志》 2012年第4期257-259,266,共4页 Journal of Diagnosis and Therapy on Dermato-venereology
基金 广东省科技计划项目(编号:2010B031600115)
关键词 Th22 银屑病
分类号 R758.63 [医药卫生—皮肤病学与性病学]
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参考文献22

  • 1Duhen T, Geiger R, Jarrossay D, et al. Production of inter- leukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells [ J]. Nat Immunol, 2009,10 (8) :857-863.
  • 2Sara T, Charles DK, Elise HT, et al. Identification of a hu- man helper T cell population that has abundant production of interleukin 22 and is distinct from Thl, Thl7 and Th2 cells [ J]. Nat Immuno1,2009,10( 8 ) :864-871.
  • 3Stefanie E, Kilian E, Davide P, et al. Th22 cells represent a distinct human T cell subset involved in epidermal im- munity and remodeling [J]. J. Clin. Invest, 2009, 119(12) :3573-3585.
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同被引文献76

  • 1陈菊华,黄春艳.复方氨肽素对进展期寻常型银屑病的疗效观察[J].现代医药卫生,2006,22(4):496-497. 被引量：5
  • 2郑敏.银屑病发病机制研究中若干问题的思考[J].中华皮肤科杂志,2006,39(3):121-123. 被引量：104
  • 3洪微,张作文.国家自然科学基金资助20年皮肤性病学基础研究发展概况[J].生命科学,2006,18(5):414-418. 被引量：4
  • 4Tan C, Aziz MK, Lovaas JD, et al. A ntigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and shortretention at the inflamm atory site [ J ]. J Immunol, 2010, 185 ( 11 ) : 6795 - 6801.
  • 5Beyer M, Schultze JL. Regulatory T cells in cancer. Blood, 2006; 108(3) : 804 -811.
  • 6Eyerich S, Eyerich K, Pennino D, et al. Th22 cells represent a dis- tinct human T cell subset involved in epidermal immunity and remod- eling. J Clin Invest, 2009 ; 119 (12) : 3573 - 3585.
  • 7Trifari S, Kaplan CD, Tran EH, et al. Identification of a human helper T cell population that has abundant production of interlenkin 22 and is distinct from Thl7, Thl and Th2 cells. Nat Immunol, 2009; 10(6) : 864 -871.
  • 8Thomas D, Rebekka G, David J, et al. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol, 2009; 10(6): 857-863.
  • 9Mosmann TR,Cherwinski H,Bond MW,et al. Two types of mu- rine helper T cell clone. I. Definition according to profiles of lym- phokine activities and secreted proteins[J]. J Immunol, 1986,136 (7) : 2348-2357.
  • 10Park H,Li Z,Yang XO,et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17[J]. Nat Immunol,2005,6(11) :1133-1141.

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皮肤性病诊疗学杂志
2012年 第4期

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