4-芳亚甲基-1-(4'-羧基苯基)-3-甲基吡唑-5-酮的三组分一锅法合成

Three component one-pot synthesis of 4-arylmethylidene-1-(4′-carboxyphenyl)-3-methyl-pyrazol-5-ones

本文报道了由乙酰乙酸乙酯、对羧基苯肼和芳香醛经三组分一锅法缩合制备4-芳亚甲基-1-(4'-羧基苯基)-3-甲基吡唑-5-酮衍生物的有效方法。实验结果表明,当以乙醇为溶剂,六氢吡啶为催化剂时,所得反应产率最高。所有产物均通过1H NMR,13C NMR,IR和MS技术进行了结构确定。

An efficient one-pot method for synthesis of 4-arylmethylidene-1-（4＇-earboxyphenyl）-3-methyl-pyrazol-5-one derivatives had been accomplished by the condensation of ethyl acetoacetate,p-carboxyphenylhydrazine and aromatic aldehydes. The results revealed that the high yields of products were obtained using piperidine as a catalyst（20% retool）in ethanol solvent. All products were characterized by ^1H NMR, ^13C NMR,IR and MS techniques.