宫颈疾病患者人乳头状瘤病毒感染分析

Human papilloma virus infections in patients with cervical lesion

目的探讨人乳头状瘤病毒(HPV)感染与宫颈疾病发生的关系,为宫颈疾病的预防及其治疗提供依据。方法分析福建省仙游县妇幼保健院2006年7月-2011年6月60例不同类型宫颈疾病患者HPV的感染情况,结合病理诊断进行分析。结果 60例宫颈病变患者中宫颈炎37例,HPV感染率为29.7%;宫颈上皮内瘤变(CIN)23例,其中CINⅠ10例、CINⅡ7例、CINⅢ6例,感染率分别为60.0%、71.4%、83.3%,中高度CIN(CINⅡ、CINⅢ)感染率明显高于低度CIN和宫颈炎(P<0.05)。结论宫颈病变的发生、发展与HPV感染有关,随着病变程度的加重,HPV感染率明显增高,HPV检测可用于宫颈疾病的筛查及治疗后的随访。

OBJECTIVE To study the relationship between the human papilloma virus（HPV） infections and cervical lesions so as to provide basis for the prevention and control of cervical lesions. METHODS A total of 60 patients with various cervical lesions who enrolled Maternal and Child Health Hospital of Xianyou from Jttl 2006 to Jun 2011 were chosen as the study objects, the condition of HPV infections in those patients was analyzed with pathological diagnosis. RESULTS Of 60 patients with cervical lesions, there were 37 cases with chronic eervicitis, the incidence of HPV infection was 29.70//00 ~ there were 23 patients with cervical intraepithelial neoplasia （CIN）, including 10 cases of CIN I , 7 cases of CIN II , and 6 cases of CIN Ⅲ the infection rates were 29.7%, 60.0%, 71.4 %, and 83.3 %, respectively. The infection rate of the patients with CIN II or CIN m was significantly higher than that of the patients with CIN or cervieitis higher than that in the cases with CIN I and chronic eervicitis （P〈 0.05）. CONCLUSION The outbreak and development of cervical lesions are related to the HPV infections, the incidence of HPV infection increases significantly as aggravating the lesions; the detection of HPV can be applied in the screening of cervical lesions and the follow-up after the treatment.