妊娠期肝内胆汁淤积症终止妊娠的时机及方式的回顾性分析

A Retrospective Study of the Relation between the Timing and Manner of Delivery and Prognosis in Intrahepatic Cholestasis of Pregnancy

目的：探讨妊娠期肝内胆汁淤积症（ICP） 终止妊娠的时机及方式对母儿结局的影响.方法：对246 例ICP 病例进行回顾性分析研究,观察ICP 孕妇终止妊娠的时机及方式与母儿结局的关系.结果：孕36～38 周终止妊娠者新生儿窒息率与羊水粪染率显著降低,选择性剖宫产终止妊娠者早产、新生儿窒息、羊水粪染、围生儿死亡率显著低于阴道分娩者.结论：对ICP 孕妇于孕36～38 周选择性剖宫产终止妊娠可明显改善围生儿预后.

Objective ：To investigate the relation between the timing and manner of delivery and prognosis in intrahepatic cholestasis of pregnancy（ICP）, Methods ：246 cases patients with ICP reported from January 2007 to September 2011 were analyzed retrospectively, the relationship between the timing and manner of delivery and the prognosis of the mother and fetus was evaluated.Results ：The rates of neonatal asphyxia and meconium-stained amniotic fluid were significantly reduced in the ICP patients who deliveried at 36 to 38 weeks of pregnancy.In addition, the rates of premature birth, neonatal asphyxia, meeonium stained amniotic fluid, and perinatal mortality of the ICP patients who took cesarean delivery were significantly lower than those of the ICP patients who took vaginal delivery.Conclusion ：Termination of pregnancy at 36 to 38 weeks of gestation by way of section of cesarean can significantly improve the perinatal fetal prognosis of ICP patients.