摘要
幽门螺杆菌是引起慢性胃炎、消化性溃疡、MALT及胃癌相关的最重要的病原体。关于幽门螺杆菌的致病机制一直以来是研究的热点,幽门螺杆菌的毒力基因对疾病的转归具有重要的影响。本文对近年来关于幽门螺杆菌最主要的两个毒力基因cagA和vacA的分子分型和流行病学调查作一综述,以对其致病机制有更加系统深入的认识。
Helicobacter pylori is the most important pathogen which is involved in chronic gastritis, peptic ulcer, MALT and gastric cancer.The most research these years is focus on the relationship between H.pylori and clinical diseases.The virulence genes play a crucial role on its prediction severe diseases. This article is based on the aim to summarize the molecular genotypes and epidemiological characteristics to get a systematic and comprehensive insight of the mechanism.
出处
《中外医学研究》
2012年第22期152-153,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
幽门螺杆菌
毒力基因
基因型
Helicobcter pylori
Virulence gene
Genotype
