非酒精性脂肪性肝病胰岛素抵抗程度与全血细胞计数的相关性

Correlation between insulin resistance and complete blood count parameters in nonalcoholic fatty liver disease

目的探讨伴或不伴2型糖尿病(T2DM)的非酒精性脂肪性肝病(NAFLD)胰岛素抵抗(IR)程度与全血细胞计数各参数的相关性。方法选取糖耐量正常并除外糖尿病史的单纯NAFLD患者102例,T2DM合并NAFLD患者104例,正常对照104例为研究对象,测定空腹血糖(FPG)、空腹胰岛素(FINS)和全血细胞计数,分析胰岛素抵抗指数(HOMA-IR)与全血细胞计数各参数的相关性。结果 T2DM合并NAFLD患者IR及全血细胞计数异常程度较单纯NAFLD患者更重;相关性研究表明男性HOMA-IR与WBC、NEU、LYM、RBC、HGB、HCT呈正相关,女性HOMA-IR与WBC、NEU、LYM、MID、RBC、HGB、HCT呈正相关。结论 NAFLD时白细胞参数和红细胞参数的变化与IR密切相关,T2DM的存在加重了IR对上述血细胞参数的影响。全血细胞计数可以作为反映NAFLD患者IR程度的一种简单实用的检验指标。

Objective To investigate the correlation between insulin resistance（IR） and complete blood count parameters in nonalcoholic fatty liver disease（NAFLD） with or without type 2 diabetes mellitus（T2DM）.Methods 102 NAFLD patients without T2DM,104 NAFLD patients with T2DM and 104 healthy controls were selected.Fasting plasma glucose（FPG）,fasting insulin（FINS） levels and complete blood count parameters were measured.The degree of insulin resistance was assessed using the homeostasis model assessment（HOMA）.Correlation between HOMA-IR and complete blood count parameters were analyzed.Results IR and complete blood count parameters of NAFLD patients with T2DM showed more abnormal than NAFLD patients without T2DM.The correlation studies indicated that HOMA-IR in male was positively related to WBC,NEU,LYM,RBC,HGB and HCT,while in female,it was also positively related to WBC,NEU,LYM,MID,RBC,HGB and HCT.Conclusions Changes of WBC and RBC parameters are closely related to the degree of IR in NAFLD.NAFLD complicated with T2DM aggravates the impact of IR on the parameters of these blood cells.Complete blood count can be used as a simple and practical laboratory test index to reflect the degree of IR in patients with NAFLD.