Wilson病患者心理理论障碍的研究

Research on theory of mind bostacles in patients with Wilson disease

目的探讨Wilson病(WD)患者的心理理论(ToM)障碍。方法对32例WD患者(WD组)以及29名健康人(NC组)进行认知功能及失言识别和眼区基本情绪辨别(喜、惊、恐、悲、厌、怒)评分,并对结果进行比较。结果与NC组比较,WD组的简易精神状态检查量表、智商、言语流畅性测试和数字广度评分差异无统计学意义。与NC组比较,WD组失言识别及心理状态判断评分显著降低(均P<0.01);眼部情绪辨别中的怒、恐和厌的评分显著降低(P<0.05～0.01),而喜、悲和惊的评分差异无统计学意义。结论 WD患者存在明显的ToM障碍,可能与其基底节损害有关。

Objective To investigate on theory of mind （ToM） obstacles in patients with Wilson disease （WD） patients, and whether in processing theory of mind of the basal ganglia. Method Thirty-two WD patients （WD group） and 29 healthy controls （NC group） were tested by cognitive function, faux pas and basic emotions recognition （joy, surprise, fear, sadness, disgust, anger） from eye area. The results were compared. Results Compared with NC group, the scores of mini-mentalstate examination, intelligence quotient （IQ） , verbal fluency test and digit span test scores in WD group were no statistical difference, but faux pas and psychological state judgment score were significantly decreased （all P 〈 0.01 ） ; the scores of anger, fear and disgust of eye emotion recognition were significantly decreased （P 〈 0.05 -0.01 ）, and the scores of joy, surprise and sadness were no statistical difference. Conclusion WD patients have ToM obstacles, and which is possible related to basal ganglia damage.