埃索美拉唑预防颅脑损伤术后并发上消化道出血的临床观察

目的总结使用埃奥美拉唑预防脑损伤术后并发上消化道出血的临床效果及相关临床经验。方法回顾性分析本院2006年7月至2011年12月间收治颅脑损伤患者救治情况,随机分为治疗组和对照一组、对照二组,治疗组预防性使用埃索美拉唑片,对照一组使用奥美拉唑,对照二组使用西咪替丁,并于治疗后第14天,对并发上消化道出血进行统计比较。结果对照二组并发上消化道出血发生率显著高于治疗组(P<0.01),治疗组与对照一组无明显差别。结论对颅脑损伤患者早期给予埃索美拉唑片进行预防性治疗,安全、经济、有效,可以降低上消化道出血发生率,改善预后。

Objective To sum up the effects of preventive treatment of Esomeprazole on patients of traumatic brain injury after operation with upper gastrointestinal hemorrhage clinical experience.Methods Treatment on patients with of traumatic brain injury after operation from July 2006 to December 2011 were analysed retrospectively.Those patients were divided randomly into therapeutic group,control group one and tow.The therapeutic group were preventive treated by omeprazole,control one group by Esomeprazole and control tow group by Cimetidine。Compared complic upper gastrointestinal hemorrhage 14 days after treatment.Results The therapeutic groups complic upper gastrointestinal hemorrhage were significantly lower than control tow group（P0.01）,and no diference with control one.Conclusion It＇s safe and economic and reliable of preventive treatment of Esomeprazole on traumatic brain injury after operation which could decrease rate of upper gastrointestinal hemorrhage and improve the prognosis.