ER、PR和P53在子宫内膜癌中的表达及其临床意义

Detection of ER,PR and P53 in Endometrial Carcinoma and Their Clinical Significance

目的:探讨ER、PR、P53在子宫内膜癌(EC)中的表达及其临床意义。方法:采集2007年1月-2011年12月57例子宫内膜癌病例资料,应用免疫组织化学法检测ER、PR和P53的表达情况并进行统计学分析。结果:ER、PR在子宫内膜癌的组织学分级表达有统计学意义(P<0.05),ER、PR的阳性表达率随着组织学分级的增高而逐渐降低。P53的阳性表达与子宫内膜癌的组织分化程度、肌层浸润及有无淋巴结转移具有统计学意义(P<0.05),不同组织学类型中表达无统计学差异。结论:子宫内膜癌组织中ER、PR、P53的表达与组织学分级密切相关,其测定是评估(EC)预后的重要指标,对于指导临床治疗具有重要意义。

Objective：To investigate the expression and clinical significance of estrogen receptor（ER）,progestin receptor（PR） and p53 in endometrial carcinoma.Methods：Clinical material was collected in 57 patients admitted in our hospital from January,2007 to December,2011.The expression of ER,PR and P53 was detected by using immunohistochemical method and analysed statistically.Results：The expression of ER and PR has significant difference statistically among different histological grade（P0.05）.The positive rates of ER and PR in endometrial carcinoma were gradually decreased with increasing of histological grade.The positive expression of P53 in EC patients has significant difference statistically on histological grade,muscular layer invading,lymphnode metastasis（P0.05）.The positive expression has no significant difference in different tissue types.Conclusion：The expression of ER,PR and P53 in tissues of endometrial carcinoma is closely related to histological grade,and the examination of these indicators has important clinical significance to evaluate prognosis of patients with EC.