心脏瓣膜钙化与增龄相关性改变

Relationship between calcification of cardiac valves and aging

目的:研究心脏瓣膜钙化的增龄性改变。方法:在我院体检行超声心动检查诊断为心脏瓣膜钙化的患者1 448例,根据年龄分为<50岁组(60例)、50～59岁组(290例)、60～69岁组(375例)、70～79岁组(279例)、80～89岁组(270例)和≥90岁组(174例)。用Logistic回归分析年龄对心脏瓣膜发生钙化的相对风险(HR)。结果:各组1个瓣膜钙化的发生率分别为3.3%(2/60)、17.2%(50/290)、46.4%(174/375)、82.4%(230/279)、91.1%(246/270)、92.5%(161/174),差异有统计学意义(P<0.01);各组2个瓣膜钙化的发生率分别为0、0、1.6%(6/375)、7.2%(20/279)、18.1%(49/270)、31.0%(54/174),差异有统计学意义(P<0.01)。年龄(每10岁)对发生心脏瓣膜钙化的HR及95%可信区间(95%CI)分别为:单因素控制,HR 3.712,95%CI 3.052～4.515,P<0.01;多因素控制,HR 3.169,95%CI2.523～3.671,P<0.01。结论:心脏瓣膜钙化随年龄增长发生率明显增加,60岁以上老年人更容易出现心脏瓣膜钙化。

Objective：To investigate the relationship between calcification of cardiac valves and aging.Method：One thousand and four hundred and forty-eight patients with calcification of cardiac valves were divided into 6 groups by age： 90 years.The relationship between calcification of cardiac valves and age was studied by Logistic regression analysis.Result：The incidences of one valve calcification in six groups were 3.3%,17.2%,46.4%,82.4%,91.1% and 92.5% respectively（P〈0.01）.The incidences of two valves calcification in six groups were 0,0,1.6%,7.2%,18.1%,31.0% respectively（P〈0.01）.When aging（for each additional 10 years） was used to predict calcification of cardiac valves,the hazard ratio was 3.712（95%CI 3.052-4.515,P〈0.01） by single-factor control and 3.169（95%CI 2.523-3.671,P〈0.01） by multiple-factors control.Conclusion：The incidence of calcification of cardiac valves increases by aging.People over 60 years old are more prone to cardiac valve calcification.