PARP-1在舌鳞癌组织中的表达及意义

Expression and Significance of Poly(ADP-ribose) Polymerase 1 in Oral Tongue Squamous Cell Carcinoma

目的检测PARP-1在舌鳞癌中的表达水平,分析与舌鳞癌患者临床病理因素及预后的相关性,初步探讨PARP-1在舌鳞癌的预后价值。方法采用免疫组织化学法检测155例舌鳞癌组织及13例邻近正常舌组织的石蜡组织切片中PARP-1的表达水平,分析PARP-1的表达水平与舌鳞癌患者的临床病理因素及预后的相关性。结果 155例舌鳞癌组织中,PARP-1阳性表达率为89.0%(138/155),其中58.1%(90/155)呈高表达,41.9%(65/155)呈低表达;13例邻近正常舌组织均无PARP-1表达,两者比较差异有统计学意义(χ2=64.815,P=0.000)。PARP-1的表达水平与患者的T分期(χ2=10.841,P=0.002)、N分期(χ2=8.962,P=0.007)、病理分期(χ2=17.151,P=0.000)呈正相关。PARP-1高表达者总生存时间(P=0.037)与无瘤生存时间(P=0.026)比低表达者短。结论 PARP-1可能是促进舌鳞癌发生发展的癌基因,具有预测舌鳞癌预后的临床价值。

Objective To detect the expression level and prognostic value of poly（ADP-ribose） polymerase 1（PARP-1） in oral tongue squamous cell carcinoma（OTSCC）,and to analysis the relationship between PARP-1 expression and the clinicopathologic characteristics and prognosis of patients.Methods Expression of PARP-1 in 155 paraffin-embedded specimens of OTSCC and 13 paraffin-embedded specimens of adjacent normal tongue mucosa tissues was detected by the immunohistochemical method.The relationship between PARP-1 expression and the clinicopathologic characteristics and prognosis of patients was analyzed.Results Expression of PARP-1 was observed in 89.0%（138/155） of 155 OTSCC specimens.Overexpression of PARP-1 was observed in 58.1%（90/155） of the 155 OTSCC Paraffin specimens,while low expression of PARP-1 was 41.9%（65/155）.Expression of PARP-1 was not observed in 13 normal tongue specimens.There was a significant difference between the 2 groups（χ2=64.815,P=0.000）.Expression of PARP-1 positively correlated to T stage（χ2=10.841,P=0.002）,N stage（χ2=8.962,P=0.007） and pathological stage（χ2=17.151,P=0.000）.The overall survival（P=0.037） and disease free survival（P=0.026） were shorter in patients with overexpression of PARP-1.Conclusion PARP-1 may play an important role in carcinogenesis and cancer progression of OTSCC.PARP-1 may have a prognostic value in OTSCC.