摘要
目的研究在不同性别中CYP4A11基因多态性与心肌梗死的关系。方法 166例心肌梗死患者和158例对照组,选择CYPA11基因的3个SNPs(rs9332978、rs3890011和rs1126742),应用TaqMan SNP基因分型法进行基因分型,并应用病例对照的研究方法进行相关性分析。结果 rs3890011的基因分型在心肌梗死组和对照组之间的分布存在明显差异(P<0.05),心肌梗死组携带GG基因型(GG vs CC+GC)高于对照组(P<0.05),在排除吸烟、高血压、糖尿病等混杂因素后,仍存在显著性差异(95%CI:1.138～2.432,P<0.01)。结论 CYP4A11基因的rs3890011多态性与心肌梗死相关,rs3890011的GG基因型可作为心肌梗死易感基因标记。
Objective To evaluate potential association between human CYP4All gene and myocardial infarction （MI）. Methods A total of 166 MI patients and 158 controls were genotyped for 3 single-nucleotide polymorphisms （SNPs） of the human CYP4All gene （rs9332978, rs3890011, rs1126742）. The data were evaluated via case- control study. Results The distribution of SNP2 （ rs3890011 ） genotypes showed significant difference between the MI and control subjects （P 〈 0. 05 ）, the distribution of the recessive model of SNP2 was significantly higher in MI patients than control subjects（ P 〈 0. 05 ）. The significance of the recessive model of SNP2 between MI patients and control subjects retained after adjustment for covariates （95% CI： 1. 138 - 2. 432, P 〈 0. 01 ）. Conclusions rs3890011 is a novel polymorphism of CYP4All gene associated with MI, GG genotype of rs3890011 functions as a genetic markers of MI.
出处
《基础医学与临床》
CSCD
北大核心
2012年第9期1036-1039,共4页
Basic and Clinical Medicine
基金
国家自然科学基金(81060020)
