ATP结合盒转运体A1基因变异与冠心病的研究进展

Research progress of ATP-binding cassette transporter A1 genovariation association with coronary artery disease

脂质代谢异常是冠心病的发病机制之一,ATP结合盒转运子A1(ABCA1)在胆固醇的逆向转运及高密度脂蛋白生成中起重要作用。ABCA1基因变异可引起脂质代谢紊乱,促进动脉粥样硬化及冠心病的发生发展。本文就近年来对ABCA1基因变异与冠心病关联性及其参与冠心病发病机制方面的研究做一综述。

Abnormal lipid metabolism plays an important role in the pathogenesis of coronary artery disease （ CAD）, ATP-binding cassette transporter A1 （ABCA1） is the rate limiting step in the reverse cholesterol transport and high density lipoprotein production. ABCA1 genovariation can cause abnormal lipid metabolism, promoting the development of atherosclerosis and CAD. This paper is about the research progress of ABCA1 genovariation and its effect on the pathogenesis of CAD.