5,6-二氢苯并[f]咪唑并[1,2-d][1,4]氧氮杂的合成

Synthesis of 5,6-dihydrobenzo[f]imidazo [1,2-d][1,4]oxazepine

目的探索合成5,6-二氢苯并[f]咪唑并[1,2-d][1,4]氧氮杂(Ⅰ)的高效、简洁的新方法。方法将线性合成方法和基于钯催化的芳香C-H键活化环合方法分别应用于化合物Ⅰ的合成,并比较两者的优劣。结果与结论两种方法都成功地实现了化合物Ⅰ的合成,其中,基于钯催化的芳香C-H键活化环合法简洁高效(二步、总收率71%)、绿色环保,为此类杂环化合物的一般合成方法。

OBJECTIVE To explore a novel and effective synthesis method for 5,6-dihydrobenzo[f]imidazo [1,2-d][1,4]oxazepine（Ⅰ）.METHODS The linear synthesis strategy and the Pd-involved cyclization strategy were applied to synthesize the heterocyclics.RESULTS and CONCLUSION The second method was featured with simplicity,high efficiency and environmental friendliness.The study provides an efficient and convenient method for synthesis of this class of compounds.