P53蛋白与P21蛋白在翼状胬肉中的表达

Expression of P53 and P21 in Pterygium

目的:探讨P53蛋白与P21蛋白在翼状胬肉中的表达。方法:应用免疫组化法检测30例翼状胬肉和正常结膜中P53蛋白与P21蛋白的表达。结果:30例翼状胬肉中P53蛋白和P21蛋白的阳性表达平均秩次分别为45.12和15.50;30例正常结膜中P53蛋白和P21蛋白的阳性表达平均秩次分别为15.88和45.50。P53蛋白与P21蛋白阳性表达在翼状胬肉中与正常结膜两组间差异有统计学意义(P<0.01)。结论:P53蛋白与P21蛋白在翼状胬肉及正常结膜中均有阳性表达,且P53蛋白在翼状胬肉中高表达,P21蛋白在翼状胬肉中低表达,说明翼状胬肉是一种组织增殖性疾病。

Objective： To investigate the role of P53 and P21 in the occurrence and develoPment of humen pterygium. Methods ：The immunohistochemical was used to examine P53 and P21 expression in 30 cases of pterygium and other 30 of normal conjunetiva. Results： The positiveexpressions of P53 and P21 in pterygium were 45.12 and 15.50 ; and in normal conjunctivawere 15.88 和 45.50. The expression of P53 and P21 between the pterygium and norreal conjunctiva were statistically signifcantboth （P 〈 0. 01 ）. Conclusions：The expression of P53 and P21 were both positive in pterygium and normal conjunctiva. The expression of P53in pterygium was significantly higher than in normal conjunctiva, and the expression of P21in pterygium was significantly lower than in normal conjunctiva. These data demonstrated that P53 and P21 may play an important role in the incidence and development pterygium.