中国人群脑胶质瘤易感性与EGF基因第61号密码子多态性的关系

Correlation of Epidermal Growth Factor（EGF） ＋61G/A Polymorphisms and Risk of Glioma in Chinese Population：A Meta-analysis

目的探讨表面生长因子（EGF）＋61G／A多态性与中国人群胶质瘤的关系。方法提取EGF基因61密码子多态性与脑胶质瘤易感性的关系的数据，筛选出符合条件的数据，应用Meta分析技术的各个软件对各项数据进行异质性检验，计算合并D刖直及95％可信区间，并行敏感性分析和发表偏倚的评估。结果该研究中共有4组符合条件的数据，病例组1，180例、对照组1，567例。4个研究合并后，AA／（AG＋GG）基因型的OR值为1．59（95％C，1．22～2．07）；亚组分析后，胶质瘤Ⅳ级AA／（AG＋GG）基因型OR值为2．18（95％C／1．56～3．04），敏感性分析表明合并结果不受单个研究的影响。结论EGF＋61G／A多态性与中国人群胶质瘤及Ⅳ级胶质瘤相关，AA基因型是中国人群胶质瘤尤其是Ⅳ级胶质瘤的高危因素。

Objective To investigate the association of the polymorphism of EGF ＋61G/A polymorphism and glioma in Chinese population.Methods Dates under the same criteria about the association of the polymorphism of epidermal growth factor（EGF） ＋61G/A and glioma in Chinese population were collected.The pool ORs with 95%CI were calculated to assess the association strength between EGF ＋61G/A polymorphisms and the risk of glioma using Meta methods.Sensitivity and publication bias were evaluated.Results Four case-controlled studies with 1,180 cases and 1,567 controls were included.Pooled data results showed the OR value of AA/（AG＋GG） was 1.59（95% CI： 1.22 -2.07）;After sub-group meta-analysis of glioma of different WHO grade, IV grade pooled data results showed the OR value of AA/（AG＋GG） was 2.18（95% CI： 1.56 -3.04）.Sensitivity analysis showed that aboved combined results could not be affected by individual study.Conclusion The results suggests that the polymorphism of the EGF ＋61G/A was significantly associated with susceptibility of glioma in Chinese population.AA genotype might be associated with the high susceptibility to glioma especially IV grade glioma.