凋亡抑制蛋白XIAP在急性髓系白血病和淋巴瘤骨髓组织中的表达及意义

Expression and Clinical Significance of XIAP Protein in the Bone Marrow Tissue of Acute Myeloid Leukemia and Lymphoma

目的:研究凋亡抑制蛋白(XIAP)在白血病及淋巴瘤骨髓活检组织中的表达及意义。方法:采用免疫组织化学法检测10例急性髓系白血病,13例淋巴瘤,9例非恶性血液病患者骨髓活检组织中XIAP的表达水平。结果:XIAP蛋白在急性髓系白血病、淋巴瘤骨髓活检组织中的阳性表达积分均高于非恶性血液病,差异均有统计学意义(P<0.05)。结论:XIAP的表达水平与白血病及淋巴瘤的发生发展有一定关联,可能与其抑制肿瘤细胞的凋亡有关。

Objective： To investigate the expression and clinical significance of the X-linked inhibitor of apoptosis protein（XIAP） in bone marrow biopsy tissue of acute myeloid leukemia and lymphoma.Methods： The expression of XIAP was detected by immunohistochemical assay in the bone marrow biopsy tissue from 10 cases of acute myeloid leukemia,13 lymphoma and 9 patients without hematological malignancy.Results： The level of XIAP in the bone marrow tissue from acute myeloid leukemia and lymphoma was higher than those from control cases without hematological malignancy（P〈0.05）.Conclusion：The increased expression of XIAP protein may contribute to the progression of acute myeloid leukemia and lymphoma,which may be relevant to its role as inhibitor of apoptosis.