D-二聚体在急性心肌梗死诊断中的应用研究

Application of D-Dimer in the Diagnosis of Acute Myocardial Infarction

目的:探讨D-二聚体在急性心肌梗死诊断中的应用价值,为提高急性心肌梗死的诊断准确性提供有益的参考。方法:以我院2010年1月至2011年1月收治的急性心肌梗死患者34例为实验组,以我院同期健康体检的34例为对照组,对两组的基础水平以及实验组溶栓治疗各时间点的D-二聚体水平进行检测分析。结果:在基础状态下实验组的D-二聚体为(1.59±0.31)mg/L,显著高于对照组(P<0.05)。实验组患者在溶栓治疗6h后的D-二聚体水平为(3.48±1.40)mg/L,显著高于溶栓治疗前(P<0.05)。其余各时间点的测量值差异无统计学意义(P>0.05)。结论:D-二聚体检测有利于急性心肌梗死患者的诊断,对临床治疗和预后有较好的指导意义,是较好的心肌梗死诊断分子标志物。在发现D-二聚体水平异常时,应结合临床症状、心电图、胸部X光片的结果进行综合判断,确保诊断的可靠性。

Objective： To investigate the application value of D-dimer in diagnosis of acute myocardial infarction,and and to bases for the accurate diagnosis of acute myocardial infarction.Methods： 34 cases of acute myocardial infarction treated from January 2010 to January 2011 in our hospital were selected as the experimental group,and 34 healthy cases in the same period were selected as control group.The D-dimer levels at each time point of thrombolytic therapy were detected and analyzed in the two groups.Results： The base state of D-dimer of experimental group was（1.59±0.31）mg/L,which was significantly higher than that in control group（P〈0.05）.The D-dimer level at 6h after thrombolytic treatment was（3.48±1.40）mg/L,which was significantly higher than that of base state（P〈0.05）.The examination results of other time was not statistically significant.Conclusion： D-dimer examination was beneficial for the diag-nosis of patients with acute myocardial infarction.It had good guideline value for clinical treatment and prognosis,so it was a good molecular marker for the diagnosis for myocardial infarction.When D-dimer level was abnormal,clinical symptoms,electrocardiogram and chest X ray film results should be combined to get comprehensive judgment,in order to ensure the reliability of diagnosis.