陀螺旋转式伽玛刀分次治疗颅内转移瘤的临床疗效观察

Gyroscope GaMaDao Rotary Cranial Metastatic Lesions of the Clinical Efficacy of Treatment Observation

目的:评价大分割伽玛射线立体定向放射治疗对颅内转移瘤的临床疗效。方法:采用陀螺旋转式伽玛射线立体定向放射设备治疗颅内转移瘤患者91例。单纯伽玛射线立体定向放射治疗采取大分割分次方式,处方剂量3.2-5Gy,每周5次,计划靶区边缘(45%或65%等剂量线处)总剂量全程为35-50Gy。结果:近期有效率(CR+PR)颅内移瘤少于3个组为93.06%(67/72),大于3个组为73.69%(14/19);局部剂量与肿瘤复发的关系,照射剂量50GY者复发率为11.86%(7/59),照射剂量为40GY者复发率为31.25%(10/32);生存率陀螺刀治疗的中位生存期为11.9个月。6、12、24个月生存率分别为:76.92%(70/91)、60.44%(55/91)、29.67%(27/91)。结论:大分割伽玛射线立体定向放射治疗脑部和体部恶性肿瘤近期疗效满意。

Objective： To evaluate the big segmentation gamma rays stereotactic radiotherapy cranial metastatic lesions of the clinical curative effect.Methods： The gyro rotary gamma rays stereotactic radiotherapy treatment equipment 91was used to treat patients with intracranial metastases.Pure gamma rays stereotactic radiotherapy took big segmentation divided second way,prescribed dose 3.2-5 Gy,five times a week,plan target area edge（45% or 65%,dose line is in） the total dose for 35 to 50 Gy.Results： In the patients（CR ＋ PR） of less than 3 intracranial move group is 93.06%（67/72）,more than three group is 73.69%（14/19）;Local dose and the relationship between the tumor recurrence,radiation dose 50 the GY recurrence rate was 11.86%（7/59）,radiation dose for the 40 GY recurrence rate was 31.25%（10/32）;Survival rate gyro knife therapy for a median was 11.9 months.6,12,24 months survival rates were 76.92%（70/91）,60.44%（55/91）,29.67%（27/91）.Conclusion： Segmentation gamma rays stereotactic radiotherapy treatments for brain and body of the malignant tumor has short-term curative effect.