中药促缺血心肌血管新生机制研究进展

Progress of Mechanisms in Traditional Chinese Medicine on Angiogenesis of Ischemic Myocardium

中药在缺血性心脏病的治疗方面具有重要作用,能够缓解症状并改善预后,促血管新生可能是其发挥作用的机制之一。已证实通过促进血管新生,可使心肌梗死面积缩小,减少细胞坏死和凋亡,改善心功能等,但其机制尚需进一步明确。目前中医药在促进梗死心肌血管新生研究方面已经取得了一定的成果,研究发现,大量中药单体、方剂及中成药具有促进血管新生作用。随着对中药促血管新生研究的不断深入,其机制的研究亦愈趋广泛,已深入到细胞及分子水平:涉及骨髓干细胞,促进血管生长的因子及其受体(血管内皮细胞生长因子、碱性成纤维细胞生长因子、胰岛素样生长因子等),抑制血管生长的因子(血管抑素、内皮抑素)及Akt/NOS/NO等通路。本文就相关研究回顾中药对缺血心肌血管新生影响并对机制进行探讨。

Traditional Chinese Medicine（TCM） has important effect in the treatment of ischemic heart disease on the relief of symptoms and improvement of prognosis.One possible underlying mechanism is TCM can promote angiogenesis.It is clear that angiogenesis can reduce area of infarcted myocardium,decrease cytoclasis and apoptosis,and improve heart function etc.But its mechanisms need further confirmed.Some achievements have been achieved about the TCM for promoting angiogenesis in infarcted myocardium.It was found that many Chinese herbal monomer,prescription and patent medicine can promote angiogenesis.With further researches,the mechanisms become more extensive and deeper into cellular and molecule levels： such as marrow stem cells,angiogenesis promotion factors and their receptors（vascular endothelial cell growth factor,basic fibroblast growth factor,insulin-like growth factor,etc）,angiogenesis inhibition factors（angiostatin,endostatin） and pathways（Akt/NOS/NO,etc）.This article is to review the mechanisms and effects of TCM on angiogenesis of ischemic myocardium based on available publications.