黄芪多糖对乙型肝炎小鼠肝脏脂肪变性的作用及机制

Effects and Mechanism of APS Using in Hepatitis B Mice with Hepatic Steatosis

目的:探讨黄芪多糖对乙型肝炎相关的肝脏脂肪变性的治疗作用及机制。方法:选取5-6周龄的SPF雄性小鼠共20只作为研究对象,随机分为研究组和对照组,各10例,研究组小鼠进行黄芪多糖溶液灌胃,对照组小鼠采用同样剂量的生理盐水灌胃。分别于用药前后测量体重(BW)、甘油三酯(TG)、谷丙转氨酶(ALT)、谷草转氨酶(AST)。结果:研究组小鼠用药后BW和TG明显低于对照组,数据经统计学比较具有显著差异(P<0.05)。用药前两组小鼠ALT和AST比较无显著差异,用药后研究组ALT和AST明显下降,与对照组用药后比较具有显著差异(P<0.05)。结论:黄芪多糖可有效降低乙型肝炎小鼠BW和血脂TG,减少ALT和AST,促进肝脏的排毒与修复,从而改善肝脏脂肪变性,缓解和治疗HBV的毒性和侵害性,提高治疗效果。

Objective： To discuss the effects and mechanism of APS using in Hepatitis B mice with hepatic steatosis. Methods： 20 SPF male mile with 5-6 weeks age old were separately distributed into Study Group with 10 cases and Control Group with 10 cases. Study Group was fed with APS solution and Control Group was fed with saline. All cases were measured of body weight （BW）, triglyceride （TG）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST） before and after taken drugs. Results： BW and TG in Study Group were significantly lower than Control Group （P〈0.05）, and ALT and AST were significantly reduced in Study Group rather and Control Group after being taken drugs （P〈0.05）. Conclusion： APS can effectively reduce the BW, lipids TG, ALT and AST of mice, promote liver detoxification and reparation, thereby improve hepatic steatosis, mitigation and treatment of HBV-toxic and invasive, improve the therapeutic effect.