C-反应蛋白检测在胎膜早破孕妇中的临床意义

The Clinical Significance of C-Reactive Protein(CRP) Detection in Pregnant Women with Premature Rupture of Membranes

目的:探讨C反应蛋白(CRP)检测在足月胎膜早破(PROM)孕妇中的临床意义。方法:选取足月胎膜早破(PROM)孕妇50例为实验组,并根据破膜时间将足月破膜孕妇分为3个亚组;并选取同期住院的正常孕妇30例为对照,采用高敏CRP试剂盒,测定不同组别孕妇中CRP水平。结果:入院时,胎膜早破各亚组中CRP水平明显高于对照组,具有显著统计学意义(P<0.05);同时随着破膜时间的增加,各亚组中的CRP水平及WBC计数也逐渐升高,且3个亚组之间也分别存在统计学差异(P<0.05)。在应用抗生素3d后,CRP出现显著下降,与正常组相比未见明显差异(P>0.05);WBC计数在应用抗生素后的3d时间出现下降,但与入院前相比未见明显统计学差异。结论:CRP检测在判断孕妇胎膜早破、指导临床用药方面具有较高的临床价值,可作为常规检查项目。

Objective： To investigate the clinical significance of C-reactive protein （CRP） detection in pregnant women with premature rupture of membranes （PROM） of full-term pregnancy. Methods： Compared with control group concluding 30 cases of normal pregnant women, there are 50 cases with premature rupture of membranes （PROM） of full-term pregnancy in the experiment group which was divided into 3 subgroups according to the time in remature rupture of membranes, and high sensitivity CRP kit was to determine the CRP level in the different groups of pregnant women. Results： Compared with the control group, the CRP levels in the patients with PROM were higher significantly in the subgroups （P〈0.05） at the time of admission. After the application of antibiotics for 3 days, CRP levels decreased significantly, which shows no significant difference （P〉0.05） compared with the control group; and WBC count also declined in the time of 3d after antibiotics using, but there were no significant statistical difference compared with time of admission. Conclusion： CRP testing can be as a routine examination in determining the pregnant women with PROM, shows the high clinical value.