厄贝沙坦及倍他乐克对高血压患者动态血压影响的比较

Comparison on influence of irbesartan and betaloc on ambulatory blood pressure monitoring of patients with hypertension

目的观察厄贝沙坦及倍他乐克对高血压患者动态血压的影响。方法选择88例初发l级原发性高血压患者,分成厄贝沙坦组及倍他乐克组各44例,分别给予相应药物治疗,治疗前及治疗后3个月行24 h动态血压检测,观察血压控制情况。结果治疗前2组患者血压无显著性差异,经治疗后2组患者血压均显著性下降(P均<0.05),2组在治疗后24 h夜均舒张压没有显著性差异,其余24 h收缩压、24 h舒张压、24 h日均收缩压和舒张压、24 h夜均收缩压均有显著性差异,厄贝沙坦组血压下降更明显。结论厄贝沙坦和倍他乐克对初发l级高血压均是较为理想的药物,厄贝沙坦组血压下降更明显。

Objective It is to observe the influence of irbesartan to betaloc on ambulatory blood pressure monitoring of pa- tients with hypertension. Methods Eighty - eight 1 - level patients with hypertension were selected and divided into two groups of irbesartan and betaloe and treated with homologous drug. The blood pressure was assessed by 24 - hour ambulatory blood pressure monitoring before treatment and after 3 months treatment. Results There were no significantly differences in blood pressure between two group patients before treatment. The blood pressures were remarkably descended after treatment in two groups （ all P 〈 0.05）. There were significant differences in 24 hours systolic pressure, 24 hours diastolic pressure, 24 hours daily average systolic and diastolic pressure, 24 hours night average systolic pressure between two groups （ all P 〈 0.05 ） ex- cept 24 hours night average diastolic pressure. The change of blood pressure in irbesartan group was more obvious. Conclusion Irbesartan and betaloc is both ideal drug for 1 - level patients with hypertension, and the effect of irbesartan is more pro- nounced.