帕罗西汀对氯胺酮镇痛效应的影响

The effect of paroxetine on analgesic effect of ketamine

目的观察帕罗西汀对氯胺酮镇痛效应的影响。方法将40只昆明种小鼠随机分为4组（每组n=10）：生理盐水（NS）组、氯胺酮（K）组、帕罗西汀（P）组、帕罗西汀＋氯胺酮（P＋K）组。利用甩尾实验测定各组小鼠用药前后的甩尾潜伏期（tail-flic klatency，TFL）。结果与Ns组相比，给药后10～40minK组小鼠TFL提高（P〈0．05或P〈0．01）。与P＋K组相比，给药后10-40minK组小鼠TFL较长（P〈0．05或P〈0．01）。结论帕罗西汀能够拮抗氯胺酮的镇痛作用。

Objective To observe the effect of paroxetine on analgesic effect of ketamine. Methods 40 mice were randomly divided into 4 groups （n=10 each）： NS group, ketamine （K） group, paroxetine （P） group, paroxetine plus ketamine （ P ＋ K） group. The tail - flick latency of each group before and after drug administration was determined by tail - flick test. Results Compared with NS group, the tail - flick latency of K group had extended from 10 rain to 40 min （ P 〈 0.05 or P 〈 0.01 ） after the drugs were administered. The tail - flick latency of K group was longer than P ＋ K group from 10 min to 40 min after the drugs were administered （ P 〈 0.05 or P 〈 0.01 ）. Conclusion Paroxetine can antagonize the analgesic effect of ketamine.