体外膈肌起搏对狗心肺功能影响

THE EFFECTS OF EXTERNAL DIAPHRAGM PACING ON CARDIOPULMONARY FUNCTION

11只健康狗在麻醉后接受体外膈肌起搏(EDP)治疗,潮气量增加近1倍(从116±40ml至210±106ml)(P<0.05)。自主呼吸被抑制后,用EDP维持呼吸,潮气量可达正常水平以上(125±50ml),并可使由于呼吸停止导致的低氧血症与二氧化碳潴留改善。无论有无自主呼吸,EDP时的心输出量均增加(分别从2.05±0.85 l/min增至2.66±0.94 1/min及1.83±0.58 1/min增至2.26±0.69 1/min),并明显优于间歇正压呼吸(P<0.05)。12只狗应用EDP作辅助呼吸,11只出现自主呼吸,1只死亡,对照组4只均死亡。表明EDP对狗的心肺功能及其复苏有明显治疗价值。

Experimental study on external diaphragm pacing (EDP) in sixteen dogs wss reported. It showed that EDP could increase tidal volume about 100 pertent (from 116±40ml to 210 ±106ml)(P<0.05)- After spontaneous responeous respiration was inhibited, tidal volumn could keep the normal level (125±50ml) and hypoxemia and hypercapnia were improved during EDP. Cardiac output increased during EDP with or without spontaneous respiration (from 2.05±0.85L/min to 2.66±0.94L/min and 1.83±0.58L/min to 2.26±0.69 L/min) and were obviously better than IPPB (P<0.05)- Eleven of twelve dogs gived EDP to support the respiration resumed their breath and one of them died. Four dogs in the control group all died. It suggests that EDP could improve ventilation, keep survival and might benifit patients with cardiopulmonary insufficiency.