男性消化性溃疡患者血浆性激素浓度的改变

PLASMA LEVELS OF SEX HORMONES IN MALE PATIENTS WITH ACTIVE PEPTIC ULCER

对24例男性活动性十二指肠溃疡(DU)和9例胃溃疡(GU)患者进行了血浆睾酮(T)、雌二醇(E_2)、孕酮(P)和血清胃泌素浓度测定。结果表明DU组血浆T浓度明显高于对照组,DU和GU组血浆P浓度均显著低于对照组。对照组血清胃泌素与血浆E_2浓度呈负相关,DU组呈正相关,GU组无相关。本研究结果提示性激素紊乱可能是消化性溃疡(PU)的发病因素之一。

The levels of testosterone (T), estradiol (E2) and progesterone (P) in plasma and gastrin in serum were determined in 24 male patients with active duodenal ulcer (DU), 9 with active gastric ulcer (GU) and 21 male healthy subjects using radioimmunoassay. It was found that plasma T levels were markedly higher in DU patients (581.7±153.9 ng/100ml) than those in healthy subjects (462.9 ±107.8ng/100ml, P<0.01). P levels were significantly lower in DU patients (0.24± 0.11ng/ml, P<0.001) and GU patients (0.25±0.09ng/ml, P<0.01) than those in healthy subjects (0.41±0.16ng/ml). We also found that plasma E2 levels had a negative correlation with serum gastrin levels in healthy subjects (r = -0.572. P<0.01). apostive correlation in DU patients (r= 0.505. P<0.02) and without correlation in GU patients (r=0.426> P>0.05)- These results of the present study suggest that the change of sex hormones levels in plasma is one of the pathogenetic factors in peptic ulcer. Plasma E2 might be an inhibitor on the release or synthesis of gastrin in normal physiological condition, and this mechanism might be defective in patients with peptic ulcer.