动脉硬化性脑梗塞遗传因素探讨

GENETIC FACTOR IN ARTERIOSCLEROTIC CEREBRAL INFARCTION

本文报道102例经CT证实的动脉硬化性脑梗塞患者及其配比对照的家系调查资料。病例一级亲属患病率(6.1％)高于对照一级亲属患病率(2.0)％,遗传度为41±7％两性的遗传度无明显差异。不同年龄组中,以≤65岁者与遗传的关系最密切。结果说明遗传因素对动脉硬化性脑梗塞尤其中年病例的发病起着重要作用。

The family information from 102 patients with arteriosclerotic cerebral infarction and their matched controls is reported. The prevalence rate for arteriosclerotic cerebral infarction in the first-degree relatives of the cases was higher that that in the first-degree relatives of the controls. The heritability was estimated as 41 ±7%. No sexual difference of herita-bility was found. The subgroup of 65 years of age was more closely associated with genetic factor in the three subgroups. These results suggest that genetic factor plays an important role in the etiology of arteriosclerotic cerebral infarction, especially in those with middle ages of onset.