摘要
机体在大剂量、长时间摄取两歧双歧杆菌后才能在其血清中检出特异性抗体 ,而非正常寄居菌———沙门氏菌经口摄取后 ,机体在很短时间内就产生较高水平的特异性抗体 ,并维持较长的时间 .进一步的研究表明 ,在体外诱导脾细胞产生免疫应答的细胞数量上 ,双歧杆菌的数量是沙门氏菌的 2 0倍 .由此推论 ,两歧双歧杆菌经口服后具有较弱的免疫原性 .
After the oral administration of a large amount of Bifidobacterium bifidum for a long time to the mice, significant amounts of anti-B.bifidum antibody were detected in the serum. However, the antibody in the mice administrated with Salmonella sp. were detected to much higher level in a short time. Furthermore, in vitro test, the optimal dose of B.bifidum to induce antibody production by spleen lymphocyte was 20 times than that of Salmonella sp.. It was demonstrated that B.bifidum was a weakly immunogenic antigen.
基金
江苏省应用基础研究项目资助!课题 (BJ970 0 0 8)
关键词
两歧双歧杆菌
免疫应答
口服
动物实验
Bifidobacterium bifidum
immune response
oral administration
