辛伐他汀对慢性心力衰竭患者功能变化及CRP、BNP水平的影响

Effects of Xinfatating on Cardiac Function and Serum Level of CRP、 BNP in Patients with Chronic Heart Failure

目的观察他汀类药物短期应用对慢性心力衰竭患者心功能、细胞因子(C反应蛋白、脑利尿钠肽)水平的影响。方法将106例慢性心力衰竭患者(NYHA分级Ⅱ～Ⅲ级)随机分为两组,治疗组(54例)和对照组(52例),两组都给予β受体阻滞剂、ACEI、利尿剂及地高辛治疗,治疗组再给予辛伐他汀40mg,每晚一次,共服6个月,治疗前后检查心脏彩超,评价心功能,测定C反应蛋白、脑利尿钠肽及血脂水平。结果 6个月后治疗组低密度脂蛋白、胆固醇水平明显降低,心功能有明显改善(P<0.01),左室射血分数有明显提高(P<0.01),C反应蛋白、脑利尿钠肽有明显的降低(P<0.01),而对照组前后无明显改变。结论辛伐他汀能降低血浆细胞因子(C反应蛋白、脑利尿钠肽)水平,改善心功能,有利于慢性心力衰竭的治疗。

Objective To study the effect of short-term statin therapy patients with chronic heart failure and to investigate the changes of serum markers of inflammation in patients with chronic heart failure.Methods A total of 106 patients with CHF （ NYHA grade II-III ） were randomized to either xinfatating 40mg/ day （ n=54 ） or control grop received placebo （ n=52 ） in a double-blinded fashion for a 6-month period.The LVEF and LV end- diastolic diameter （ LVDd ） were determined by echocardiography, and the parameters of C-reactive protein（CRP）, brain natriuretic peptide （ BNP ） and serum cholesterol were measured, before and after treatment.Resu I ts The LVEF increased in the xinfatating group over the 6-month follow-up period, whereas those patients in the placebo group experienced a decline in ejection fraction during the same time period.In addition, LVDd was reduced and was reduced in the cohort of patients treated with xinfatating, these dimensions increased in the placebo group.There were significant reductions in serum levels of CRP and BNP in the xinfatating group.Conclusion Short-term xinfatating improves cardiac function, reduce levels of serum CRP, BNP and cholesterol associated with CHF.