220例剖宫产患者围手术期抗菌药物应用情况对比分析

Comparative analyses on perioperative utilization of antibiotics in 220 patients undergoing cesarean section

目的分析抗菌药物整治前后剖宫产患者围手术期抗菌药物应用情况,为临床合理用药提供依据。方法采用回顾性分析方法,对我院产科2009年3～5月及2012年1～3月住院患者220份病历资料进行调查,探讨围手术期抗菌药物合理应用情况。结果抗菌药物整治前后剖宫产患者围手术期抗菌药物总的使用率分别为95.5%,94.4%,平均用药时间分别为4.7d,3.8d,最长预防用药时间分别为7d,6d。结论经过抗菌药物整治以后,剖宫产患者抗菌药物的使用率下降了1.1%,平均用药时间缩短0.9d,二联及三联用药比例分别下降了22.9%,2.6%。最长预防用药时间缩短1d。但是仍存在抗菌药物的品种选择不恰当,联合用药不合理,抗菌药物使用时间过长,用药时机不规范,用法用量不规范,标本送检率低等问题。应进一步加强抗菌药物使用监管,促进围手术期合理用药。

Objective To investigate antibiotic utilization during perioperative period in cesarean section cases, and to provide basis for rational medication in clinic. Methods Retrospective study was done on 220 cases of cesarean section discharged from our hospital during March to May in 2009 and January to March in 2012 to discuss the rationality of perioperative antibiotic utilization. Results The ratio of peroperative use of antibiotics for patients undergoing cesarean section, before and after control of antibacterials, were 95.5 % and 94. 4 % respectively, with the average durations of prophylaxis at 4. 7 and 3.8 days and the longest durations at 7 and 6 days. Conclusion After control of antibacterials, the rate of antibacterial utilization for cesarean section patients has decreased by 1.1%, the average duration of medication has shortened by 0. 9 day, the rate of two-drug and three-drug utilization has decline in 22. 9% and 2. 6% respectively. The longest duration of perioperative antibiotic prophylaxis has shortened by 1 day. However, there still exist some problems, such as inap- propriate choice of drugs, irrational combination therapy, long course of treatment, improper medication timing, nonstandard usage and dosage, low rate of specimens tested etc. It is necessary to strengthen supervision in order to promote rationality of perioperative antibiotic utilization.