胰岛素样生长因子在胃癌中的表达与意义

THE EXPRESSION OF INSULIN- LIKE GROWTH FACTOR IN GASTRIC CARCINOMA

目的探讨胰岛素样生长因子-Ⅰ(insulin-like growth factor-Ⅰ,IGF-Ⅰ)、胰岛素样生长因子-Ⅱ(insulin-like growth factor-Ⅱ,IGF-Ⅱ)在胃癌中的表达及与胃癌浸润转移等生物学行为的关系。方法对胃癌患者40例的癌组织、距原发灶5cm以上切缘组织和正常胃组织标本10例进行IGF-Ⅰ、IGF-Ⅱ免疫组织化学染色。结果①胃癌组织中IGF-Ⅰ的表达率显著高于切缘组织和对照组(P<0.05);切缘组织和对照组中表达率差异无统计学意义(P>0.05);病理分期中Ⅰ、Ⅱ期与Ⅲ、Ⅳ期比较差异有统计学意义(P<0.05);无淋巴结转移组与淋巴结转移组相比差异有统计学意义(P<0.05);未侵及全层组与侵及全层组相比差异有统计学意义(P<0.05)。②胃癌组织中IGF-Ⅱ的表达率显著高于切缘组织和对照组(P<0.05)。切缘组织和对照组中表达率差异无统计学意义(P>0.05)。病理分期中Ⅰ、Ⅱ期与Ⅲ、Ⅳ期比较差异有统计学意义(P<0.05);无淋巴结转移组与淋巴结转移组相比差异有统计学意义(P<0.05);未侵及全层组与侵及全层组相比差异有统计学意义(P<0.05)。结论 IGF-Ⅰ、IGF-Ⅱ的高表达与胃癌的发生有关,且均参与了胃癌的侵袭和转移。

Objective To investigate the relationship of the expression of insulin - like growth factor- Ⅰ （IGF - Ⅰ ） and insulin - like growth factor - Ⅱ （IGF - Ⅱ ） with the histological type, pathologic tumor - node - metastasis （PTNM） stage, infiltration as well as metastasis of gastric carcinoma （GC）. Methods The expression of IGF - Ⅰ and IGF - Ⅱ were tested by S - P immunohistochemistry in 40 cases of GC tissues, margin tissues which were more than 5cm from primary focus in distance and 10 cases of normal gastric mucosa. Results ①The expression rate of IGF - Ⅰin GC group was much higher than in margin tissues and normal gastric mucosa groups （ P 〈 0.05 ）. There was no significant difference between margin tissues group and normal gastric mucosa groups （ P 〉 0.05 ）. The expression of IGF - Ⅰ was closely correlated to the tumor PTNM stage,lymph node metastasis and depth of infiltration （P 〈 0.05 ）.②The expression rate of IGF -Ⅱ in GC group was much higher than in margin tissues and normal gastric mucosa groups （ P 〈 0.05 ）. There was no significant difference between margin tissues group and normal gastric mucosa group （ P 〉 0.05 ）. The expression of IGF - ]] was closely correlated to the tumor PTNM stage, lymph node metastasis and depth of infiltration （ P 〈 0. 05 ）. Conclusion The excessive expression of IGF - Ⅰ and IGF - Ⅱ is closely correlated to carcinogenesis of GC. It may be involved in the development, infiltration and metastasis of GC.