摘要
山梨醇脱氢酶(sorbitol dehydrogenase或SDH)是多元醇代谢通路中的关键酶,可将底物D-山梨醇、L-艾杜淳、D-木糖醇、D-半乳糖醇等氧化成果糖。催化需要金属离子Zinc和辅酶NAD+。SDH特异性抑制剂直接作用于SDH-NADH复合体,通过阻止产物的释放而抑制酶反应。在近些年对于不同生物打破滞育的研究中发现SDH是滞育胚胎再度开始发育的关键酶。对SDH结构,催化机制以及其与不同物种滞育之间关系的研究进展进行综述。
Sorbitol dehydrogenase is a key enzyme in the polyol pathway,which oxidizes D-sorbitol,L-iditol,D-glucitol,D-xylitol,D-galactitol into fructose.The catalytic process needs the combination of Zinc and NADH.The Sorbitol dehydrogenase inhibitor binds to the SDH-NADH complex and competitive with fructose.SDH plays a key role in the process of termination of diapause,and of redevelopment of embryo of many different species.This review summarizes the structure and catalytic mechanism of SDH,and its role in the process of diapause of different species.
出处
《安徽农学通报》
2012年第15期39-40,84,共3页
Anhui Agricultural Science Bulletin
关键词
山梨醇脱氢酶
作用机制
滞育
Sorbitol dehydrogenase
Mechanism
Diapause
