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Survivin蛋白和BRAF基因在甲状腺癌中的表达 被引量：7

Study on the expression of Survivin and BRAF in thyroid carcinoma
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摘要 甲状腺癌是头颈部常见的恶性肿瘤。如何鉴别及确定良、恶性甲状腺结节并估计预后的特异性肿瘤分子标记物对于甲状腺肿瘤患者的诊断和治疗具有重要意义。本文就与甲状腺癌发生发展及预后相关的BRAF基因和Survivin蛋白的表达两个方面予以综述。 Thyroid cancer is common malignant tumors in head and neck.How to distinguish and to make a definite diagnosis of benign or malignant thyroid nodules and prognosis of the specific tumor marker for molecular diagnosis of thyroid cancer patients and treatment are much important.In this paper,we reviewed the development of thyroid cancer,the prognosis of BRAF gene and protein expression of survivin.
作者 石光清 曹艳
机构地区 中南大学湘雅三医院核医学科
出处 《中国现代医学杂志》 CAS CSCD 北大核心 2012年第19期61-66,共6页 China Journal of Modern Medicine
关键词 甲状腺癌 BRAF基因 SURVIVIN thyroid carcinoma BRAF gene surviving
分类号 R736.1 [医药卫生—肿瘤] R730.2 [医药卫生—肿瘤]
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二级参考文献37

  • 1Ru Tao Cui,Gan Cai,Zhao Bao Yin,Yong Cheng,Qiu Hong Yang,Tao Tian.Transretinoic acid inhibits rats gastric epithelial dysplasia induced by N-methyi-N-nitro-N-nitrosoguanidine:influences on cell apoptosis and expression of its regulatory genes[J].World Journal of Gastroenterology,2001,7(3):394-398. 被引量：8
  • 2An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book..Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer[J].World Journal of Gastroenterology,2001,7(3):403-406. 被引量：91
  • 3Zhong Zhang~1 Yuan Yuan Hua Gao Ming Dong Lan Wang Yue-Hua Gong 1 Department of Pathology,Shenyang Medical College,Shenyang 110031 Liaoning Province,China.Apoptosis,proliferation and p53 gene expression of H.pylori associated gastric epithelial lesions[J].World Journal of Gastroenterology,2001,7(6):779-782. 被引量：46
  • 4项永兵,金凡,袁剑敏,孙璐,高玉堂.肿瘤登记资料统计分析的微机实用软件[J].中国慢性病预防与控制,1994,2(2):74-76. 被引量：5
  • 5Davies L,Welch HG. Increasing incidence of thyroid cancer in the United States, 1973-2002 [J]. JAMA,2006,295( 18 ):2164-2167.
  • 6Gerard AC,Daumerie C,Mestdagh C,et al.Correlation between the loss of thyroglobulin iodination and the expression of thyroid-specific proteins involved in iodine metabolism in thyroid carcinomas [J]. J Clin Endocrinol Metab, 2003,88 (10) : 4977-4983.
  • 7Elisei R,Pinehera A,Romei C,et al. Expression of thyrotropin receptor (TSH-R), thyroglobulin, thyroperoxidase, and calcitonin messenger ribonucleic acids in thyroid carcinomas:evidence of TSH-R gene transcript in medullary histotype [J ]. J Clin Endocrinol Metab, 1994,78(4) : 867-871.
  • 8Durante C, Puxeddu E, Ferretti E,et al. BRAF mutations in papillary thyroid carcinomas inhibit genes involved in iodine metabolism [J]. J Clin Endocrinol Metab, 2007,92(7 ) : 2840-2843.
  • 9Sodre AK, Rubio IG,Galro AL,et ah Association of low sodium-iodide symporter messenger ribonucleic acid expression in malignant thyroid nodules with increased intracellular protein staining [J]. J Clin Endocrinol Metab,2008,93(10) :4141-4145.
  • 10Baylin SB,Ohm JE. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? [J]. Nat Rev Cancer, 2006,6(2) : 107-116.

共引文献111

同被引文献92

  • 1丁艳,王宁,陈晓杰,徐冶.Survivin在甲状腺癌中的研究进展[J].吉林医药学院学报,2013,34(4):289-292. 被引量：2
  • 2Smolle E,Taucher V,Petru E,et al.Targeted treatment of ovarian cancer--the multiple-kinase-inhibitor sorafenib as a potential option[J].Anticancer Res,2014,34(4):1519-1530.
  • 3Campos M,Ducatelle R,Kooistra HS,et al.Immunohistochemical expression of potential therapeutic targets in canine thyroid carcinoma[J].J Vet Intern Med,2014,28(2):564-570.
  • 4Mancikova V,Inglada-Pérez L,Curras-Freixes M,et al.VEGF,VEGFR3,and PDGFRB Protein Expression Is Influenced by RAS Mutations in MedullaryThyroid Carcinoma[J].Thyroid,2014,24(8):1251-1255.
  • 5Yu GP,Li JC,Branovan D,et al.Thyroid cancer incidence and survival in National Cancer Institute survcillance'epidemiology'and end results race/ethnicity groups[J].Thyroid,2010,20(5):465.
  • 6Kim SJ,Lee KE,Myong JP,et al BRAFV600Emutation is associated with tumor aggressiveness in papillary thyroid cancer[J].World J Surg,2012,36(2):310.
  • 7Basolo F,Torregrossa L,Giaannini R,et al.Correlation between the BRAFV600Emutation and tumor invasivenese in papillary thyroid carcinomas smaller than 20 millimeters:analysis of 1060 cases[J].J Clin Endocrinol metab,2010,95(9):4197.
  • 8Sassolas G,Hafdi-Nejjari Z,Ferraro A,et al.Oncogenic alterations papillary thyroid cancers of young patients[J].Thyroid,2012,22(1):17.
  • 9Cooper DS,Doherty GM,Haugen BR,et al.Revised management guidelines for patients with thyroid nodules and differentiated thyroid cancer[J].Thyroid,2009,19(11):1167.
  • 10Kleiman DA,Buitrago D,Crowley MJ,et al.Thyroid stimulating hormone increases iodine uptake by thyroid cancer cells during BRAF silencing[J].The Journal of surgical research,2013,182(1):85.

引证文献7

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中国现代医学杂志
2012年 第19期

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