柳氮磺吡啶保留灌肠联合双歧三联活菌治疗溃疡性结肠炎的疗效观察

Clinical Observation of Salicylazosulfapyridine Enema Oral and Enema Oral Combination Therapy of Ulcerative Colitis

目的:探讨柳氮磺吡啶保留灌肠联合双歧三联活菌治疗溃疡性结肠炎的疗效。方法:将84例溃疡性结肠炎(UC)患者随机分为2组,柳氮磺吡啶保留灌肠联合双歧三联活菌组(治疗组)和单纯柳氮璜吡啶保留灌肠组(对照组),各42例,疗程均为4周。结果:治疗前、后2组临床症状、肠镜分级、病理组织学分级变化均具有统计学意义(P<0.05)。结论:柳氮磺吡啶保留灌肠联合双歧三联活菌治疗溃疡性结肠炎疗效明显优于单用柳氮璜吡啶保留灌肠。

Objective：The objective of the study was to probe into a more effective therapy in the treatment of ulcerative colitis.Methods：84 cases with ulcerative colitis were random divided into two groups：treatment group（42 cases）and control group（42 cases）.The patients in treatment group received SASP enema while the patients in control group received with oral SASP.Results：Before and after treatment group 2 clinical symptoms,colonoscopy classification,pathological changes histologic classification are statistically significant.Conclusion：Enema with SASP is an effective treatment of ulcerative colitis.