生脉注射液对心源性休克患者血氧饱和度及乳酸的影响

Effect of Shengmai injection on blood oxygen saturation and lactic acid in patients with cardiogenic shock

目的:探讨生脉注射液对心源性休克患者中心静脉血氧饱和度(venous oxygen saturation,ScvO2)及动脉血乳酸(lactic acid,Lac)的影响。方法:将60例符合标准的心源性休克患者随机分为治疗组(30例)和对照组(30例),两组均给予西药常规治疗,治疗组同时给予生脉注射液持续静滴,对照组给予5%葡萄糖注射液持续静滴。分别在用药前、用药后2,6和12 h行中心静脉和动脉血气分析,检测ScvO2和Lac的变化。结果:治疗组用药后2,6和12 h ScvO2水平明显高于对照组,差异有统计学意义(P<0.05)。治疗组用药后2,6和12 h乳酸浓度均低于对照组相同时点的乳酸浓度,差异有统计学意义(P<0.05)。结论:在西药常规复苏治疗基础上加用生脉注射液治疗心源性休克患者,较单纯西药常规复苏治疗能更好地升高ScvO2、降低乳酸水平和增加氧摄取,提示生脉注射液可改善心源性休克患者的全身氧代谢状况。

Objective： To investigate the effect of Shengmai injection on central venous oxygen saturation （ScvO2） and lactic acid （Lac） in patients with cardiogenic shock. Methods： Sixty patients meeting the standard of cardiogenic shock were randomly divided into 2 groups （30 patients in each group）. Patients in both groups were treated with either routine therapy alone or combined with intravenous infusion of Shengmai injection. The central venous and arterial blood was respectively collected before medication, and 2, 6, 12 h after the administration to evaluate the levels of the ScvO2 and Lac. Results： The ScvO2 level was significantly higher and lactic acid concentration was significantly lower in Shengmai group than in control group 2, 6, 12 h after the administration （P 〈 0.05）. Conclusion： Combined treatment with Shengmai injection is beneficial to raise ScvO2 level, reduce Lac level, and improve oxygen metabolism in patients with cardiogenic shock.