氮酮对骨平巴布膏中延胡索乙素在体经皮吸收的影响

Effect of Azone on in vivo Percutaneous Absorption of Tetrahydropalmatine from Guping Cataplasm

目的:探讨氮酮对骨平巴布膏中延胡索乙素在体经皮吸收的影响。方法:采用膏体剩余量法,测定延胡索乙素的剩余量,模拟延胡索乙素透皮吸收的动力学方程式。结果:延胡索乙素的透皮吸收表现为一级动力学模式,随氮酮用量的增加,透皮吸收量越高,吸收速率越大。结论:氮酮质量分数3%和5%的制剂透皮吸收量均较大,且无显著差异,结合时滞影响的考虑,确定氮酮用量3%。

Objective： To investigate influence of azone on in vivo percutaneous absorption of tetrahydropalmatine from Guping cataplasm. Method： Paste residual quantity method was used by determining remnant amount of tetrahydropalmatine, its kinetic equation of transdermal absorption was simulated. Result： Transdermal absorption of tetrahydropalmatine showed first-order kinetics, rate of absorption and absorbed dose were enhanced when dosage of azone raised. Conclusion ： There was no significant deviation between mass fraction of azone 3% and 5% , which both had great absorbed dose, consideration by combining with effect of lag time, we determined the amount of azone 3%.