黄芪注射液对支气管哮喘急性发作的疗效及对细胞免疫功能的影响

Influences of Astragalus Injection on Clinical Efficacy and Cellular Immune Function in Patients of Bronchial Asthma with Acute Exacerbation

目的:探讨黄芪注射液配合常规疗法治疗支气管哮喘急性发作的疗效及其对T淋巴细胞亚群比率、自然杀伤细胞(NK)的影响。方法:将72例支气管哮喘急性发作期患者随机分为对照组(常规疗法)和黄芪组(常规疗法+黄芪注射液),疗程14 d。观察两组临床疗效并检测治疗前、后外周血T淋巴细胞亚群CD3+,CD4+,CD4+/CD8+的变化。结果:治疗后黄芪组的临床控制率和总有效率(68.6%,97.1%)显著高于对照组(43.2%,78.4%)(P<0.05);治疗前黄芪组和对照组的CD3+,CD4+,CD4+/CD8+及NK均显著低于健康组(P<0.01);治疗后黄芪组CD3+,CD4+,CD4+/CD8+及NK[(61.47±5.31)%,(39.60±5.36)%,(1.61±0.41),(31.79±4.11)%]均显著高于治疗前(P<0.01)和对照组[(56.02±4.51)%,(33.30±5.22)%,(1.27±0.52),(29.60±4.41)%](P<0.01或P<0.05);黄芪组的不良反应发生率显著低于对照组(P<0.05)。结论:在常规疗法的基础上联用黄芪注射液治疗支气管哮喘急性发作能明显提高临床疗效,同时可减轻使用激素所产生的不良反应,这与黄芪注射液能改善T淋巴细胞和NK细胞的免疫功能有关。

Objective： To observe effects of astragalus injection on immune functions of sub-populations of T lymphocyte and natural killer ceils （NK-cell） in patients of bronchial asthma with acute exacerbations. Method： Seventy two patients with acute bronchial asthma were divided randomly into two groups, namely control group （conventional therapy） and astragalus group （conventional therapy ＋ astragalus injection）. The effects of treatment were observed; the changes in T lymphocyte and CD3^＋, CD4^＋, CD8^＋, CD4^＋/CD8^＋ in peripheral blood were detected. Result： After treatment of 14 days, the clinical control rate and the total efficiency of the astragalus group （68.6% , 97.1% ） were significantly higher than that of the control group （43.2% , 78.4% ） （P 〈0. 05）. Before treatment, CD3 ^＋, CD4^＋, CD4^＋/CD8^＋ and NK in the astragalus group and the control group were significantly lower than that of the healthy group （P 〈 0.01 ）. After treatment, CD3 ^＋ , CD4^＋ ,CD4 ^＋/ CD8^＋ and NK in the Astragalus group [ （61.47±5.31）%, （39.60±5.36）%, （1.61±0.41）, （31.79±4. 11） % ] were significantly higher than that before treatment （P 〈 0.01.） and the control group [ （56.02± 4.51）%, （33.30±5.22）%, （1.27±0.52）, （29.60±4.41）%] （P〈0.01 orP〈0.05）. Adverse reaction rate in the astragalus group was significantly lower than that in control group （ P 〈 0.05 ）. Conclusion ： On the basis of routine treatment, combined with astragalus injection can improve the effects for the treatment of acute bronchial asthma, while it is able to relieve the harmful reactions induced by using steroids. The mechanism may be related to the improvement of immune function of T lymphocyte and NK-cells.