基于GLUT4转位的中药及活性成分改善胰岛素抵抗研究进展

Recent Advances on Chinese Medicine and Active Ingredients in Ameliorating Insulin Resistance via GLUT4 Translocation

对中药通过调控葡萄糖转运蛋白4(glucose transporter 4,GLUT4)转位而改善胰岛素抵抗(insulin resistance,IR)的研究进展进行总结。GLUT4转位研究对IR的机制研究以及药物作用靶点的选择都具有重要意义。本文主要从磷脂酰肌醇3-激酶/非典型蛋白激酶C/蛋白激酶B(PI3K/PKC/Akt),AMP活化蛋白激酶(AMP-activated protein kinase,AMPK)等关键途径,介绍各种中药活性成分、单方及复方通过调控GLUT4转位对IR的改善作用及机制,为防治IR中药的临床合理使用及新药开发提供参考。

To summarize the research progress in the treatment of insulin resistance （IR） via glucose transporter 4 （GLUT4） translocation with Chinese medicine. Translocation of GLUT4 to plasma membrane plays a key role in regulating whole body glucose homeostasis, and experiments carried out in GLUT4 translocation might give significant results on IR mechanism and drug targets screening. In order to facilitate the clinical rational treatment of IR and develop new potential drug from Chinese medicine, this review will assess the current researchstatus in the treatment of IR via GLUT4 drug and compound preparations, which activated protein kinase （AMPK）. translocation with mainly via several Chinese medicine including active ingredients, single key pathways such as PI3K/ PKC/ Akt and AMP-activated protein kinase （AMPK）.