他汀类药物对兔缺血心肌中血管新生的影响

Effect of statins on neovascularization in rabbit ischemic myocardium

目的:研究他汀类药物对兔缺血心肌中血管新生的影响。探讨怎样促进梗死心肌和严重冠心病患者心肌的侧支循环重建以促进疾病的康复和减少其并发症。方法:应用阿托伐他汀干预心肌梗死高胆固醇动物模型,观察他汀类药物对缺血心肌中血管新生的影响。取动物模型动物梗死边缘区心肌组织做冰冻切片,用酶组化染色法检测毛细血管内皮细胞的碱性磷酸酶鉴定。结果:他汀类药物对缺血心肌中血管新生有影响。结论:阿托伐他汀对缺血心肌中血管新生有促进作用,但具体机制有待进一步研究。

Objective To investigate the effect of statins on neovascularization in rabbit ischemic myocardium, and to investigate how to regenerate collateral circulation in patients with myocardial infarction and severe coronary. Methods Atorvastatin was applied in animal models of myocardial infarction with high cholesterol, the effect of statins on neovascularization in ischemic myocardium was studied. The marginal zone of the infarcted myocardium in animal models was used to prepare frozen thin sections, Alkaline phosphatase in capillary endothelial ceils was detected by enzyme-histochemical staining technique. Results Statins affected neovascularization in ischemic myocardium of animal models of myocardial infarction with high cholesterol. Conclusion Atorvastatin can promote neovascularization in ischemic myocardium, but the mechanism underlying needs further research.