摘要
目的探讨肥胖青少年血清睾酮与代谢综合征（MS）的关系。方法选取14～30岁的肥胖青少年574例为研究对象，分为MS组（n=305例，其中男87例，女218例）和非MS组（n=269例，其中男60例，女209例）。应用化学发光法测定血清睾酮水平。结果男性中，MS组的睾酮水平低于非MS组[（3．0±1．1）ng／ml和（3．5±1．4）ng／ml，P〈0．01]；睾酮与体质量指数（BMI）、腰围、空腹血糖（FPG）、空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA—IR）、三酰甘油（TG）呈负相关。女性中，MS组与非MS组睾酮水平比较差异无统计学意义[（0．8±0．3）ng／ml和（0．8±0．4）ng／ml，P〉0．05]。睾酮与收缩压（SBP）、FINS、HOMA—IR呈正相关。无论男性还是女性，睾酮与MS各组分的多重回归分析显示只有HOMA—IR与睾酮水平独立相关。结论肥胖青少年男性血清睾酮水平与代谢综合征密切相关。肥胖青少年女性睾酮与代谢综合征之间的关系仍需进一步研究。胰岛素抵抗可能是代谢综合征与睾酮之间相互作用的关键因素。
Objective To investigate the relationship between serum testosterone and metabolic syndrome（MS） in overweight and obese young. Methods 574 cases of overweight and obese young were assigned to metabolic（MS） group and non-metabolic syndrome（NMS） group. The level of serum testoster- one was measured by chemiluminescent microparticle immunoassay. Results In obese young male, testos- terone was lower in MS group than that in NMS group [ （ 3.0 ± 1.1 ） ng/ml vs. （ 3.5 ±1.4 ） ng/ml, P 〈 0. 01 ] and was negative correlated with body mass index（BMI）, waist circumference, fasting plasma glu- cose（FPG） ,fasting insulin（FINS） , HOMA-IR and triglycerides （TG）. In obese young female, there was no difference between MS group and NMS group[ （0.8 ± 0.3 ） ng/ml vs. （0.8 ±0. 4 ） ng/ml ,P 〉 0.05 ] in testosterone levels. Testosterone was positively correlated with diastolic blood pressure（SBP） ,fasting insu- lin and HOMA-IR. Multiple regression analysis showed only HOMA-IR was an independent factor related to testosterone in both male and female. Conclusion Metabolic syndrome is closely correlated with serum testosterone level. In obese young female,the relationship between testosterone and MS still needs further research to confirm. Insulin resistance is probably the key factor between MS and serum testosterone.
出处
《临床内科杂志》
CAS
2012年第7期463-466,共4页
Journal of Clinical Internal Medicine
基金
基金项目：上海市科学技术委员会专项资助项目（10dz1920802）
关键词
代谢综合征
睾酮
肥胖
胰岛素抵抗
Metabolic syndrome
Testosterone
Obesity
Insulin resistance
