高血压患者血尿酸水平与冠状动脉病变的关系

Relationship between uric acid and coronary lesion in patients with hypertension

目的探讨高血压患者血尿酸水平与冠状动脉病变程度的关系。方法51例非高血压患者及120例高血压患者行冠状动脉造影检查，冠脉狭窄≥50％者为冠心病组，冠脉造影未见异常者为冠脉正常组，再按照病变严重程度将高血压病合并冠心病患者分为单支、双支、3支病变3组，并检测血尿酸水平及血糖、血脂等生化指标。结果高血压患者冠脉造影阳性率为75．85％，高于非高血压组，两组比较差异有统计学意义（P〈0．01）；高血压合并冠心病患者血尿酸水平高于单纯高血压患者，且升高程度与冠状动脉病变程度呈正相关（P〈0．01或P〈0．05）。结论高血压患者冠心病发病率高于非高血压患者，高血压合并冠心病患者血尿酸水平高于非冠心病患者，尿酸升高程度与冠脉病变程度一致。

Objective To study the relationship between serum uric acid and coronary lesion in patients with hypertension. Methods 171 patients undergoing diagnostic coronary angiography were di- vided into coronary heart disease（CHD） group（ ≥50% diameter narrowing） and control group. 120 pa- tients with hypertension were further divided into four subgroups, the single-vessel group, the double-vessel group,the three-vessel group and non-CHD group. Serum uric acid,blood glucose,total cholesterol（TC） , triglycerides （ TG ）, high-density lipoprotein （ HDL）, low- density lipoprotein （ LDL ） were measured in all of the four groups of patients with hypertension. Results In patients with hypertension, the positive rate of diagnostic coronary angiography was 75.85% ;and in patients without hypertension ,the ratio of diagnostic coronary angiography was 70.69% （ P 〈 0.01 ）. The levels of serum uric acid were higher in hypertension and CHD group than those of hypertension and non-CHD group（ P 〈 0.01 ）. And the higher levels of ser- um uric acid were corresponded with the more severity of coronary lesion in hypertension and CHD pa- tients. Conclusion There is higher morbidity and more complicated coronary lesion in hypertension than those of the non-hypertension. High level of uric acid may be indirectly assessing the coronary lesion.