Pd(OAc)_2/CuI共催化杂环C—H键与芳基溴的直接芳基化反应研究

The direct arylation of benzoxazoles with aryl bromides cocatalyzed by Pd(OAc)_2 and CuI

研究开发了一个实用高效的Pd(OAc)2/CuI共催化体系,只需在1%Pd(OAc)2,10%CuI,0.5 mol PPh3配体存在下,苯并唑类杂环与各种芳基溴的直接芳基化反应就能够在温和的反应条件下顺利进行,并得到良好的收率。

A practical, efficient Pd（OAc） 2/CuI cocatalytic system has been developed. With only 1% Pd- （OAc） 2,10% CuI, and 0.5 mol of inexpensive PPh3 as ligand, the direct arylation of benzoxazoles with aryl bromides could be performed smoothly in mild condition, affording the desired arylated benzoxazoles in good yields.