摘要
Objective： To observe and compare the effects of mild moxibustion and Chinese medicine on the paw edema and pain threshold in rats with experimental arthritis. Methods： Forty-six male Wistar rats were randomly divided into 5 groups, a control group （10 rats）, a model group （9 rats）, a Chinese medicine （CM） group （9 rats）, a moxibustion group （9 rats） and a Western medicine （WM） group （9 rats）. Except rats in the control group, rats in the other four groups were established to be arthritis model by cold stimulation and Freund＇s adjuvant. After modeling, rats in the control group and the model group were not treated. The remaining three groups were respectively treated with traditional Chinese medicine, moxibustion and Western medicine. Then the changes in the rat paw swelling and pain threshold were observed. Results： The paws of rats＇ swelled significantly after injection of adjuvant. After 7 d of treatment, the rats＇ paws of CM group were still markedly swollen, and compared with the CM group, the swelling of the paws in the WM group and the moxibustion group were statistically significant （P〈0.05）. The rats＇ mechanical pain threshold of the WM group, CM group and the moxibustion group were significantly higher than that of the model group with statistical significance （all P〈0.05）. In CM group, it was higher than in the WM group with statistical significance （P〈0.05）. That in moxibustion group was higher than that in the WM group without significance between the groups （P〉0.05）. Latent period of rat＇s paw withdrawal threshold of the thermal pain in western medicine group was significantly longer than that in the model group with statistically significant （P〈0.05）. But latent period of rat＇s paw withdrawal threshold of the thermal pain in the CM group and the moxibustion group extended without statistical significance （P〉0.05）. Conclusion： The mechanical pain threshold of rats with experimental arthritis can be significantly improved by mild moxibustion and Chinese medicine treatment, which have a certain analgesic effect on rats with experimental arthritis pain.
目的:观察比较温和灸与中药对实验性关节炎大鼠足跖肿胀及痛阈的影响。方法:将46只雄性Wistar大鼠随机分为5组,对照组10只,模型组、中药组、艾灸组和西药组每组9只。除对照组外,其他4组采用冷刺激与弗氏佐剂结合诱导大鼠关节炎模型。造模成功后,对照组、模型组不予治疗。其余3组分别接受中药、艾灸和西药治疗,观察大鼠足跖肿胀度及痛阈变化。结果:造模大鼠佐剂注射后足跖均出现明显肿胀。治疗7 d后,中药组大鼠足跖仍有明显肿胀;西药组和艾灸组大鼠足跖肿胀度,与中药组比较差异均有统计学意义(均P<0.05),与模型组比较差异均无统计学意义(均P>0.05)。西药组、中药组和艾灸组大鼠的机械痛阈均明显高于模型组,组间差异均有统计学意义(均P<0.05);其中中药组高于西药组,组间差异有统计学意义(P<0.05);艾灸组高于西药组,但组间差异无统计学意义(P>0.05)。西药组大鼠热疼痛缩足闽潜伏期明显长于模型组大鼠,组间差异有统计学意义(P<0.05);中药组和艾灸组热疼痛缩足阈潜伏期较模型组虽有延长趋势但无统计学意义(P>0.05)。结论:温和灸和中药均能明显提高实验性关节炎大鼠的机械痛阈,且有一定的镇痛作用。
基金
supported by Science and Technology Innovation Plan for Undergraduate of Zhejiang Province (2010R410001)
