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17型T辅助细胞相关因子在肺部炎症与纤维化中作用

Role of T helper type 17-related cytokines in pulmonary inflammation and fibrosis
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摘要 17型T辅助（Th17）细胞是一类新发现的与白细胞介素（IL）-23相关，并能分泌IL—17的新型Th细胞亚群，在细胞分化及生物学作用等方面均不同于1型T辅助（Th1）细胞和2型T辅助（Th2）细胞，被认为是一个独立的辅助T细胞亚群。肺间质纤维化是多种病因引起的异质性疾病，主要病理特点是弥漫性肺泡炎、成纤维细胞增殖、大量细胞外基质积聚、肺泡单位结构紊乱和肺纤维化，具体发病机制尚未完全明了，临床治疗也未获得较好效果。
作者 周春英 袁宝军
机构地区 河北联合大学附属开滦医院检验科
出处 《中国职业医学》 CAS 北大核心 2012年第4期350-351,共2页 China Occupational Medicine
关键词 17型T辅助细胞肺部炎症肺纤维化细胞因子
分类号 R135 [医药卫生—劳动卫生]
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参考文献22

  • 1BETTELLI E, KORN T, KUCHROO V K. Th17: the third member of the effector T cell trilogy[J]. Curr Opin lmmunol, 2007, 19(6) : 652 - 657.
  • 2ZHAI R, GE X, LI H, et al. Differences in cellular and inflammatory cytokine profiles in the bronchoalveolar lavage fluid in bagassosis and silicosis[J]. Am J Ind Med, 2004, 46(4) : 338 -344.
  • 3OUYANG W, KOLLS J K, ZHENG Y. The biological functions of T helper 17 cell effector cytokines in inflammation [ J]. Immunity, 2008, 28(4) : 454 -467.
  • 4DECRAENE A, WILLEMS-WIDYASTUTI A, KASRAN A, et al. Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patients[ J]. Respir Res, 2010, 11 (1): 177-184.
  • 5WILSON M S, MADALA S K, RAMALINGAM T R, et al. Bleomycin and IL-lbeta-mediated pulmonary fibrosis is IL-17A dependent [J]. JExpMed, 2010, 207(3) : 535 -552.
  • 6M! S, LI Z, YANG H Z, et al. Blocking IL-17A promotes the resolu- tion of pulmonary inflammation and fibrosis via TGF-betal-dependent and -independent mechanisms [ J ]. J Immunol, 2011, 187 (6) : 3003 - 3014.
  • 7SIMONIAN P L, ROARK C L, WEHRMANN F, et al. Thl7-pola- rized immune response in a murine model of hypersensitivity pneumo- nitis and lung fibrosis[J]. J Immunol, 2009, 182( 1 ) : 657 -665.
  • 8SIMONIAN P L, ROARK C L, WEHRMANN F, et al. IL-17A-ex- pressing T ceils are essential for bacterial clearance in a murine model of hypersensitivity pneumonitis [ J ]. J Immunol, 2009, 182 (10) : 6540 - 6549.
  • 9LO RE S, DUMOUTIER L, COUILLIN I, et al. IL-17A-producing gammadeha T and 33117 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis [ J]. J Immunol, 2010, 184 ( 11 ) : 6367 - 6377.
  • 10吴静,徐建,张映铭,王彩英.矽肺患者血清IL-17检测的临床意义[J].放射免疫学杂志,2009,22(6):623-625. 被引量：10

二级参考文献9

  • 1李庆,李廷,祁新兰.煤工尘肺患者血清TNF-α、sIL-2R、IL-6和IL-8检测的意义[J].中国工业医学杂志,2006,19(1):11-12. 被引量：21
  • 2Zhai R, Ge X, Li H, et al. Differences in cellular and irdtammatory cytokine profiles in the bronchoalveolar lavage fluid in bagassosis and silicesis[J]. Am J Ind Med, 2004,46:338-344.
  • 3白明,李元桂,主译.现代肺部疾病诊断与治疗[M].第1版.北京:人民卫生出版社,2006,2790.
  • 4Kolls JK, Kanaly ST, Ramsay AJ. Interleukin-17 : an emerging role in lung inflammation[J]. Am J Respir Cell Mol Biol, 2003,28: 9-11.
  • 5Larsson R. Rocksen D, Lilliehook B, et al. Dose-dependent activa- tSon of lymphocytes in endotoxin-induced airway inflammation[ J]. Infect Immun, 2000,68: 6962-6969.
  • 6Escotte S, Tabary O, Dusser D, et al. Fluticasone reduces 132-6 and IL-8 production of cystic fibrosis bronchial epithelial cells via IKK-beta kinase pathway[J]. Eur Respir J, 2003, 21:574-581.
  • 7Shen N, He B, Wang J, et al. Significance of anti-interleukin-17 antibodies to airway inflammation in cigarette smoke-induced COPD in mice [J]. Am J Respir Crit Care Med, 2009,179: A2955.
  • 8Molet S, Hamid Q, Davoine F, et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines[ J ]. J Allergy Clin Immunol, 2001,108: 430-438.
  • 9Hnizdo E and Vallyathan V. Chronic obstructive pulmonary disease due to occupational exposure to silica dust: a review of epidemiological and pathological evidence[ J]. Occup Environ Med, 2003, 60: 237-243.

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中国职业医学
2012年 第4期

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